Knots

Call it Murphy's Law of knots: If something can get tangled up, it will. "Anything that's long and flexible seems to somehow end up knotted," says Andrew Belmonte, an applied mathematician at Pennsylvania State University in University Park. Now, scientists think they may have found out how and why things find their way into knotty arrangements. By tumbling a string of rope inside a box, biophysicists Dorian Raymer and Douglas Smith have discovered that knots—even complex knots—form surprisingly fast and often. The string first coils up, and then its free ends swivel around the other coils, tracing a random path among them. That essentially makes the coils into a braid, producing knots, the scientists say. The results' relevance may go well beyond explaining the epidemic of tangled venetian blind cords. That's because spontaneous knots seem to be prevalent in nature, especially in biological molecules. For example, knottiness may be crucial to the workings of certain proteins (see "Knots in Proteins"). And knots can randomly form in DNA, hampering duplication or gene expression—so much so that living cells deploy special knot-chopping enzymes.

Topology studies shapes. Specifically, it studies shapes' properties that are not affected by stretching, moving, twisting, or pulling—anything that doesn't break up the object or fuse some of its parts. The proverbial example is that, to a topologist, a coffee mug is the same as a doughnut. In your imagination, you can squash the mug into a doughnut shape, and it will retain the property of having a hole, namely its handle.

A sphere is different. You can stretch a sphere into a stick and bend the stick so its ends touch. But turning that open ring into a doughnut will involve fusing the ends, and that's forbidden.
In topology, a knot is any curved line that closes up on itself, possibly after a circuitous path in three dimensions. A circle is regarded as the "trivial" knot. Two loops are considered to be the same knot if you can turn one into the other by topological manipulation, which in this case means anything that does not break the curve or force it to run through itself.

Topologically, a knotted string is not a real knot, as long as its ends are free. That's because either of the ends can always thread back through any entanglement and undo the knot. An open string, no matter how garbled, is the same as a straight segment. (Mathematicians usually think of strings as being stretchable and infinitesimally thin, so in topology there is no issue of a knot being tight.)

Topologists usually work with two-dimensional drawings of knots called knot projections. From different points of view, the same curve will look different and so will its projections. Topologists' best tools for distinguishing knots are algebraic expressions called knot polynomials. These are sums of multiples of a variable, such as x, raised to different powers. The variable has no meaning per se, and all the information is in the numbers by which it's multiplied. But the x's make it easier to calculate a knot polynomial starting from a knot projection.